CRPS, Pain Relief, Complex Regional Pain Syndrome, Peripheral Neuropathy, Pain Treatment, Pain Management, Carolina Pain Scrambler Center, Greenville South Carolina

Complex Regional Pain Syndrome Info

Complex regional pain syndrome is a rare, chronic, and sometimes progressive condition. It involves spontaneous or evoked pain in a region, or area of the body.

It usually affects one of the arms, legs, hands, or feet after an injury, but complications can impact the whole body, including the internal organs.

It appears to be an autoimmune condition, in which the body responds in an unusual way to a perceived threat. As the immune system fights to defend the body, inflammation occurs.

Symptoms that distinguish the pain of complex regional pain syndrome (CRPS) from that of other types of pain are autonomic and inflammatory signs such as changes in skin color, temperature, or sweating.

A person who develops CRPS after experiencing an injury may find that they have pain that is more severe than they would normally have expected with such an injury.

CRPS can affect people of any age, but it usually appears between the ages of 40 and 70 years, and it is more common among females.

Severity ranges from self-limiting and mild to severe and debilitating.


The severity and frequency of symptoms vary widely. Some people have repeated episodes, while others find that symptoms disappear forever after a few months.

There are two types of CRPS:

Type 1: An apparently trivial injury, such as a fractured or sprained ankle, has occurred, but with no confirmed nerve damage. This type was previously known as reflex sympathetic dystrophy.

Type 2: This may emerge after breaking a bone, having surgery, or after a serious infection. There is clear evidence of nerve damage. This type was previously known as causalgia.

However, debate about the classification of these types is ongoing. Since nerve injury is sometimes found in people with type 1, the National Institute of Neurological Disorders and Stroke (NINDS) notes that the distinction between the two categories may be removed at some point.

Some experts suggest that Trusted Source type 1 is not CRPS at all, but that is it either a normal reaction or the result of treatment received after a trauma.


Symptoms include severe and continuous pain, often in part or all of a limb. It has been described as “burning” or a combination of burning and electrical shocks.

Pain may radiate

If CRPS happens after an injury, the pain of the injury may be unusually severe. For example, an ankle sprain may trigger an unbearable burning sensation. The pain may not be limited to the area where the injury occurred.

Damage to a toe or finger, for example, may lead to pain in the whole limb, or even pain in the opposite extremity.

The affected part can become hypersensitive. Touching, bumping, or exposing the limb to temperature changes may cause severe pain.

Muscle atrophy, or wasting, can result, if the patient stops using the limb because of the pain.

There may also be:

  • changes in skin temperature
  • fluid retention (edema) and sweating
  • changes in skin color, causing blotches or streaks, ranging from very pale to pink, and perhaps with a blue tinge
  • changes to finger and toenails
  • thin and shiny skin texture
  • unusually fast or slow nail and hair growth
  • painful, stiff, and inflamed joints
  • difficulty co-ordinating muscle movement
  • unusual movement in the limb

The limb may be fixed in an abnormal position or may experience movements such as jerking or tremors.

Mobility can be reduced, as it becomes difficult to move the affected part.


As mentioned above, CRPS may develop following an injury or surgery. The exact cause is not clear, but multiple mechanisms may be involved.

Research published in 2005 lists the likely mechanisms as:

  • trauma-related release of cytokines, substances produced by the immune system
  • exaggerated inflammation in the nervous system
  • changes to the nervous system that cause the pain to continue

Some people may have an existing abnormality in the peripheral nerves that make them more sensitive if damage occurs. If the individual experiences an injury, they may react to it in a different way than most people do.

Some theories propose that inflammation and changes in the brain and sympathetic, peripheral, and spinal nervous systems, aggravated by immobility, may contribute.

CRPS does not always result from an obvious injury. It may happen because of damage that has occurred internally, such as a blood vessel problem.

If CRPS occurs in members of the same family, it may be more severe, suggesting that genetic factors may play a role or make some people more susceptible.


If a patient seeks medical help, and they may have CRPS, the doctor will ask about their medical history and will look for swollen joints and changes in skin temperature and appearance.

The diagnosis is based on clinical findings that exclude other possible causes.

A number of diagnostic tests can help eliminate other causes and confirm a diagnosis.

Blood tests can help exclude infection or inflammation in the joints as a possible cause of symptoms.

Scans, such as ultrasound, may be used to rule out a blood clot, known as deep vein thrombosis.

Thermography measures skin temperature of specific parts of the body. High or low skin temperature in the affected area could indicate CRPS.

Electrodiagnostic testing, or nerve conduction studies, involve attaching wires to the skin and measuring the electrical activity of nerves. Abnormal readings could indicate nerve damage, and possible type 2 CRPS.

X-rays can detect mineral loss in the bones at later stages.

An MRI scan, a blood test or a biopsy can rule out underlying problems with bones or tissue.


There is little definitive treatment for CRPS, and the course is best determined by the doctor who treats it. Early treatment is most effective, and it is best for a specialty pain clinic to assess and determine a plan.

Treatment may involve a neurologist, a physical therapist, and other specialists.

Applying ice may help.

As CRPS affects the nervous system, it can lead to a wide range of complications throughout the body.

Issues that have been linked to CRPS include:

  • chest pain
  • changes to the way the body perceives and manages pain
  • problems with thinking and memory
  • lethargy, fatigue, and weakness
  • rapid pulse and heart palpitations
  • breathing problems
  • fluid retention
  • muscle weakness, bone loss, and other musculoskeletal problems
  • rashes, mottling, and other skin problems
  • urological problems such as difficulty urinating or incontinence
  • gastrointestinal problems, including nausea, vomiting, diarrhea, and symptoms of irritable bowel syndrome (IBS)
  • gastroesophageal reflux
  • low cortisol levels and hypothyroidism

If the condition remains untreated or treatment starts late, there may be muscle wasting and contracting of the hand, fingers or foot, as the muscles tighten.