Use of Calmare Therapy in treating Amplified Musculoskeletal Pain Syndrome (AMPS): A case report

Calmare therapy has been used to treat refractory neuropathic pain in cancer patients cause by chemotherapy. Calmare therapy works by sending no-pain signal via multiple skin electrodes applied near areas where patient is experiencing pain. The “no-pain” signals sent from the device overrides the pain signals thus providing relief. In this case study a previously healthy 12-year-old male started having episodes of fevers with arthralgias at age 10. He complained of abdominal and muscle pain along with weakness when exercising. He was presumptively treated for Lyme disease but he continued to have recurrent fevers with arthralgia. His symptoms were managed with antipyretic and non-steroidal anti-inflammatory drugs. He was seen by several subspecialties: infectious disease, rheumatology, hematology, cardiology, gastroenterology, neurology and underwent extensive tests including immunologic and genetic testing which were normal. He was given the diagnosis of amplified musculoskeletal pain syndromes (AMPS). When establishing care with pain clinic to be evaluated for Calmer Therapy he was scheduled to complete an inpatient program at children’s hospital of Philadelphia the following month for AMPS. On initial visit, he complained of left hip pain, subjective bilateral leg weakness and abdominal pain. After evaluation, patient agreed to proceed with 10 one-hour sessions of Calmare therapy. During each session, a total of ten electrodes were placed around both knees, near painful abdominal areas and right hip. After second session, he reported a decrease in his stomach pain by one point on VAS scale from 8 to 7. After the fifth session, his right knee pain and stomach pain were 1 and 2/10 (VAS). After his sixth session, he reported right hip pain was 1/10 (VAS). After completing all the sessions patient reported zero hip and knee pain. Calmare therapy may potentially be used to treat other forms of pain such as AMPS. (Moon JY1, Kurihara C, Beckles JP, Williams KE, Jamison DE, Cohen SP. Clin J Pain. 2015 Aug;31[8]:750-6)